Would you like to register Outlook as the default manager?' Displayed message. Clicking Yes updates the following registry entries which you can also manually update (and will need to for older Outlook clients such as Outlook 97) Start the registry editor (regedit.exe) Move to HKEY_LOCAL_MACHINE SOFTWARE Clients Mail.

Outlook 98 and Outlook 2000 will prompt you when starting to set as the default mail client if they are not already configured as such however if you checked the 'Don't ask me this again' box you cannot display this dialog. To force Outlook 98 and 2000 to check type the following: C: > 'c: program files microsoft office office outlook.exe' /checkclient Click Yes to the 'Outlook is not currently your default manager for Mail and News. Would you like to register Outlook as the default manager?' Displayed message.

'Either there is no default mail client or the current mail client cannot fulfill the messaging request. Please run Microsoft Outlook and set it as the default mail client.' One user experiencing this error message when he starts up and logs into his machine, also at seemingly random times during the day. Windows 7 Pro fully patched 64-bit Office 2010 Pro Plus 32-bit Adobe Reader DC (as I think Reader has something to do with this) (Worth noting: Lync 2013 aka Skype for Business is installed on the machine) I've tried the obvious stuff: Make sure Outlook 2010 is set as the default mail client Run a repair on Office 2010 Make sure all updates have been run Then I started looking at other solutions, including setting up a different default mail service within Adobe Reader. I also saw something suggesting to disable the Reader Speed Loader at startup. There was also a recommendation to set the bitness for Office 15 in regedit to x64.tried this even though I didn't expect it would work since we're using 32-bit Office 14. I'd love to get this nuisance issue out of my user's way.

Adam Gadoury wrote: Have you tried a full uninstall and reinstall of Office already? Normally a registry file issue with this error so you may need to uninstall clean registry and preferences then reinstall. This fixed the issue for me as well. One of our users got this error when Right-click on a document > Send to > Mail recipient. Using Office 365 ProPlus x86. Tried setting Outlook as the default mail client in every possible way to no avail. In the end, removing Office using MS Fixit tool (then reboot), reinstall Office from O365-portal (then reboot) and running all MS updates (multiple reboots) fixed this issue for me.